Description of target: Component of the mediator complex, a coactivator involved in regulated gene transcription of nearly all rna polymerase ii-dependent genes. mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal rna polymerase ii transcription machinery. mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with rna polymerase ii and the general transcription factors. phosphorylates the ctd (c-terminal domain) of the large subunit of rna polymerase ii (rnap ii), which may inhibit the formation of a transcription initiation complex. phosphorylates ccnh leading to down-regulation of the tfiih complex and transcriptional repression. recruited through interaction with maml1 to hyperphosphorylate the intracellular domain of notch, leading to its degradation (by similarity).;Species reactivity: Mouse;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: <0.053ng/mL
5311.49RON
În stoc
Număr Catalog 247-OKDD00790CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
