Description of target: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4f (eif4f), which is a cap binding protein complex that consists of three subunits: eif4a, eif4e and eif4g. the protein encoded by this gene shares similarity with the c-terminal region of eif4g, that contains the binding sites for eif4a and eif3; eif4g in addition, contains a binding site for eif4e at the n-terminus. unlike eif4g which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. transgene expression of the apolipoprotein b mrna-editing enzyme (apobec-1) causes extensive editing of this mrna, which could contribute to the potent oncogenesis induced by overexpression of apobec-1. in vitro and in vivo studies in human indicate that translation of this mrna initiates exclusively at a non-aug (gug) codon. this also appears to be true for mouse. two alternatively spliced transcript variants that encode different isoforms have been found for this gene.;Species reactivity: Mouse;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: <0.066 ng/mL
5311.49RON
În stoc
Număr Catalog 247-OKDD00721CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
