Accidentul vascular cerebral – cele mai importante informații
Pe măsură ce înaintăm în vârstă, riscul de a ...
NR1D1 ELISA Kit (Human) (OKCD00732)
Description of target: Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner.10 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus."_x005F_x005F_x000D_Miyajima N., Horiuchi R., Shibuya Y., Fukushige S., Matsubara K., Toyoshima K., Yamamoto T._x005F_x005F_x000D_Cell 57:31-39(1989) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.Ref.2"Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone."_x005F_x005F_x000D_Lazar M.A., Jones K.E., Chin W.W._x005F_x005F_x000D_DNA Cell Biol. 9:77-83(1990) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.Ref.5"Orphan nuclear hormone receptor Rev-erbalpha regulates the human apolipoprotein CIII promoter."_x005F_x005F_x000D_Coste H., Rodriguez J.C._x005F_x005F_x000D_J. Biol. Chem. 277:27120-27129(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.6"The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene."_x005F_x005F_x000D_Yin L., Lazar M.A._x005F_x005F_x000D_Mol. Endocrinol. 19:1452-1459(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.7"The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1."_x005F_x005F_x000D_Wang J., Yin L., Lazar M.A._x005F_x005F_x000D_J. Biol. Chem. 281:33842-33848(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.10"Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways."_x005F_x005F_x000D_Yin L., Wu N., Curtin J.C., Qatanani M., Szwergold N.R., Reid R.A., Waitt G.M., Parks D.J., Pearce K.H., Wisely G.B., Lazar M.A._x005F_x005F_x000D_Science 318:1786-1789(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, HEME-BINDING.Ref.11"Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha."_x005F_x005F_x000D_Wu N., Yin L., Hanniman E.A., Joshi S., Lazar M.A._x005F_x005F_x000D_Genes Dev. 23:2201-2209(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.15"Direct regulation of CLOCK expression by REV-ERB."_x005F_x005F_x000D_Crumbley C., Burris T.P._x005F_x005F_x000D_PLoS ONE 6:E17290-E17290(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.18"The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines."_x005F_x005F_x000D_Gibbs J.E., Blaikley J., Beesley S., Matthews L., Simpson K.D., Boyce S.H., Farrow S.N., Else K.J., Singh D., Ray D.W., Loudon A.S._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 109:582-587(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.19"DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha."_x005F_x005F_x000D_Chini C.C., Escande C., Nin V., Chini E.N._x005F_x005F_x000D_Biochem. J. 451:453-461(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH CCAR2, PHOSPHORYLATION AT SER-55 AND SER-59, UBIQUITINATION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 11.6 pg/mL
4467.46 RON
În stoc
Număr Catalog 247-OKCD00732CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
Produse asociate
Bloguri asociate
Contact
Ai întrebări? Contactează-ne telefonic
Belgia (BE): +32 2 265 09 20
Franța (FR): +33 1 88 38 07 37
Regatul Unit (UK): +44 20 33 938 531
Polonia (PL): +48 58 710 33 44
Germania (DE): +49 241 936 88 188
Statele Unite (US): +1 408 780 09 08
- [email protected]
Strada Avram Iancu 7B, 075100 Otopeni, Romania
© 2026 Toate drepturile rezervate | Gentaur RO
