Description of target: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).6 Publications
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.7"The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response."_x005F_x005F_x000D_Carney J.P., Maser R.S., Olivares H., Davis E.M., Le Beau M., Yates J.R. III, Hays L., Morgan W.F., Petrini J.H.J._x005F_x005F_x000D_Cell 93:477-486(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN DSB REPAIR, IDENTIFICATION IN THE MRN COMPLEX WITH MRE11A AND NBN.Ref.8"Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95."_x005F_x005F_x000D_Trujillo K.M., Yuan S.-S.F., Lee E.Y.-H.P., Sung P._x005F_x005F_x000D_J. Biol. Chem. 273:21447-21450(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN DSB REPAIR, IDENTIFICATION IN THE MRN COMPLEX WITH MRE11A AND NBN.Ref.9"The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks."_x005F_x005F_x000D_Paull T.T., Gellert M._x005F_x005F_x000D_Mol. Cell 1:969-979(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, ATP-BINDING, MUTAGENESIS OF LYS-42 AND ASP-1231.Ref.13"Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres."_x005F_x005F_x000D_Zhu X.-D., Kuester B., Mann M., Petrini J.H.J., de Lange T._x005F_x005F_x000D_Nat. Genet. 25:347-352(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN TELOMERES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE A COMPLEX WITH TERF2, SUBCELLULAR LOCATION.Ref.15"Human Rad50/Mre11 is a flexible complex that can tether DNA ends."_x005F_x005F_x000D_de Jager M., van Noort J., van Gent D.C., Dekker C., Kanaar R., Wyman C._x005F_x005F_x000D_Mol. Cell 8:1129-1135(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTRAMOLECULAR COILED-COIL DOMAINS.Ref.19"Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex."_x005F_x005F_x000D_Lee J.-H., Paull T.T._x005F_x005F_x000D_Science 304:93-96(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN ATM ACTIVATION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.057 ng/mL
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Număr Catalog 247-OKCD00590CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
