Description of target: Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity).By similarity1 Publication
 <p>Manually curated information for which there is published experimental evidence.</p>
 
 
 <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.3"Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells."_x005F_x005F_x000D_Chandra A., Itakura T., Yang Z., Tamakoshi T., Xue X., Wang B., Ueki T., Sato K., Uezato T., Miura N._x005F_x005F_x000D_Biochem. Biophys. Res. Commun. 344:786-791(2006) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, GLYCOSYLATION, DEVELOPMENTAL STAGE. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.054 ng/mL
4607.23RON
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Număr Catalog 247-OKCD00473CategorieAfaceri și industrie > Știință și laboratorFurnizorAviva Systems BiologyGentaurDimensiune96 WellsTipsingle
