PF15 TFA is a PROTAC connected by ligands for FLT3 kinase and CRBN. PF15 TFA is a high selective FLT3-ITD degrader,with a DC50 of 76.7 nM. PF15 TFA significantly inhibits the proliferation of FLT3-ITD-positive cells,can down-regulate the phosphorylation of FLT3 and STAT5. PF15 TFA also inhibits tumor growth in mouse models and can be used in study of leukemia[1].
16679.04RON
În stoc
Număr Catalog 804-HY-143286ACategorieAfaceri și industrie > Știință și laboratorFurnizorMedChemExpressGentaurDimensiune1 mgTipsingle