AR-42 (HDAC-42; OSU-HDAC42) is a potent, orally bioavailable pan-HDAC inhibitor (IC50=16 nM). AR-42 induces growth inhibition, cell-cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. AR-42 shows cytotoxicity against various human cancer cell lines[1][2].
766.25EUR
În stoc
Număr Catalog 804-HY-13265CategorieAfaceri și industrie > Știință și laboratorFurnizorMedChemExpressGentaurDimensiune10 mgTipsingle