Catalytic activity:ATP-dependent breakage| passage and rejoining of double-stranded DNA.|enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.|Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils| whereas prokaryotic enzymes relax only negative supercoils.|PTM:Phosphorylation has no effect on Catalytic activity.|Belongs to the type II topoisomerase family.|subcellular location:Generally located in the nucleoplasm.|subunit:Homodimer. Interacts with COPS5.|
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Număr Catalog 772-BT-AP13123-100ulCategorieAfaceri și industrie > Știință și laboratorFurnizorJiaxing Korain Biotech Ltd (BT Labs)GentaurDimensiune100ulTipsingle