The Fanconi anemia complementation group (FANC) currently includes FANCA| FANCB| FANCC| FANCD1 (also called BRCA2)| FANCD2| FANCE| FANCF| FANCG| FANCI| FANCJ (also called BRIP1)| FANCL| FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability| hypersensitivity to DNA crosslinking agents| increased chromosomal breakage| and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage| resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repai
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Număr Catalog 772-BT-AP00681-100ulCategorieAfaceri și industrie > Știință și laboratorFurnizorJiaxing Korain Biotech Ltd (BT Labs)GentaurDimensiune100ulTipsingle