The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelian tumors of the neck and head, leading to the development of anticancer therapeutics targeting EGFR. EGFR(T790M) mutation is found as a second-site mutation in ~50% of EGFR-mutated lung tumors. The mutant was shown to be resistant to most tyrosine kinase inhibitor medicines including Erlotinib and Gefitinib. The EGFR(T790M) Kinase Assay Kit is designed to measure EGFR (T790M) Kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The EGFR (T790M) Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant EGFR(T790M) enzyme, EGFR substrate, ATP and kinase assay buffer for 100 enzyme reactions.
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Număr Catalog 421-40323CategorieAfaceri și industrie > Știință și laboratorFurnizorBPS BioscienceGentaurDimensiune96 rxns.Tipsingle
